Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 10/20 | 0.48 |
| ▸ | PPARG | P37231 | 10/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 3/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5210899 | 0.95 | PPARA (0.49) | PPARAPPARGHCRTR1HCRTR2MEN1 | |
| SCHEMBL5209719 | 0.93 | PPARG (0.47) | PPARAPPARGFFAR1CYP2C9KCNH2 | |
| SCHEMBL2514695 | 0.90 | PPARG (0.51) | PPARAPPARGHCRTR1HCRTR2MEN1 | |
| SCHEMBL2514696 | 0.90 | PPARG (0.51) | PPARAPPARGHCRTR1HCRTR2MEN1 | |
| SCHEMBL5211867 | 0.88 | PPARG (0.48) | PPARAPPARGFFAR1CYP2C9KCNH2 | |
| SCHEMBL5210317 | 0.88 | FFAR1 (0.52) | PPARAPPARGFFAR1MMP1ADAM17 | |
| SCHEMBL5205909 | 0.88 | PPARA (0.49) | PPARAPPARGFFAR1MMP1ADAM17 | |
| SCHEMBL5213499 | 0.87 | MAPT (0.42) | PPARAPPARGHCRTR1HCRTR2MEN1 | |
| SCHEMBL5205913 | 0.87 | FFAR1 (0.50) | PPARAPPARGFFAR1 | |
| SCHEMBL5208392 | 0.86 | PPARA (0.55) | PPARAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448523-B1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | NOVARTIS AG (CH) | 2007-08-22 | — | — | EP | claimed |