Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 4/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.52 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.49 |
| ▸ | AXL | P30530 | 1/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.44 |
| ▸ | DHFR | P00374 | 2/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5212680 | 0.89 | BACE1 (0.44) | BACE1EPHX2PRMT6CYP2A6DHFR | |
| Ammonia Solution, Strong SCHEMBL4936578 | 0.85 | BACE1 (0.61) | BACE1EPHX2PRMT6MEN1PSIP1 | |
| SCHEMBL9694096 | 0.84 | MPO (0.48) | CYP2A6CYP11B1CYP11B2ALDH1A1CYP1A2 | |
| SCHEMBL5213984 | 0.79 | BACE1 (0.63) | BACE1DHFR | |
| SCHEMBL5244112 | 0.79 | CYP11B1 (0.52) | BACE1CYP11B1CYP11B2ALDH1A1CYP19A1 | |
| SCHEMBL5214222 | 0.77 | DHFR (0.46) | BACE1MEN1DHFRALDH1A1CYP1A2 | |
| SCHEMBL7499087 | 0.74 | LTA4H (0.43) | BACE1CYP3A4MPO | |
| SCHEMBL1130071 | 0.73 | EPHX2 (0.63) | BACE1EPHX2PRMT6MEN1PSIP1 | |
| SCHEMBL3780918 | 0.73 | CYP2A6 (0.73) | BACE1EPHX2PRMT6MEN1PSIP1 | |
| SCHEMBL29809603 | 0.73 | CYP2A6 (0.73) | BACE1EPHX2PRMT6MEN1PSIP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831170-A1 | SUBSTITUTED AMINOPYRIDINES AND USES THEREOF | AstraZeneca AB (SE) | 2007-09-12 | — | — | EP | claimed |
| WO-2006065204-A1 | SUBSTITUTED AMINOPYRIDINES AND USES THEREOF | ASTRAZENECA AB (SE) | 2006-06-22 | — | — | WO | claimed |
| EP-1831170-A1 | SUBSTITUTED AMINOPYRIDINES AND USES THEREOF | AstraZeneca AB (SE) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006065204-A1 | SUBSTITUTED AMINOPYRIDINES AND USES THEREOF | ASTRAZENECA AB (SE) | 2006-06-22 | — | — | WO | disclosed |