Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 5/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.52 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 2/20 | 0.44 |
| ▸ | NOS3 | P29474 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5215267 | 0.83 | ABCB1 (0.47) | BACE1HTR1ADRD2ALDH1A1 | |
| SCHEMBL5214956 | 0.80 | CCR5 (0.52) | LTA4HMAPK14ALDH1A1 | |
| SCHEMBL5247113 | 0.80 | BACE1 (0.67) | LTA4HMAPK14BACE1 | |
| SCHEMBL14007526 | 0.79 | BACE1 (0.69) | CYP11B1CYP11B2CYP19A1LTA4HMAPK14 | |
| SCHEMBL5214947 | 0.79 | BACE1 (0.56) | CYP11B1CYP11B2CYP19A1BACE1ALDH1A1 | |
| SCHEMBL5215584 | 0.77 | LTA4H (0.45) | LTA4HMAPK14 | |
| SCHEMBL14259206 | 0.77 | CYP11B1 (0.63) | CYP11B1CYP11B2CYP19A1LTA4HMAPK14 | |
| SCHEMBL30453373 | 0.74 | CYP11B1 (0.63) | CYP11B1CYP11B2CYP19A1LTA4HMAPK14 | |
| SCHEMBL488124 | 0.74 | CYP11B1 (0.63) | CYP11B1CYP11B2CYP19A1LTA4HMAPK14 | |
| SCHEMBL9694096 | 0.72 | MPO (0.48) | CYP11B1CYP11B2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831170-A1 | SUBSTITUTED AMINOPYRIDINES AND USES THEREOF | AstraZeneca AB (SE) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006065204-A1 | SUBSTITUTED AMINOPYRIDINES AND USES THEREOF | ASTRAZENECA AB (SE) | 2006-06-22 | — | — | WO | disclosed |