Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCAT2 | O15382 | 1/20 | 0.61 |
| ▸ | DHODH | Q02127 | 2/20 | 0.50 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.50 |
| ▸ | TTR | P02766 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | PTPRC | P08575 | 2/20 | 0.47 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | KMO | O15229 | 1/20 | 0.47 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL944091 | 0.91 | BCAT2 (0.63) | BCAT2DHODHFOLH1IKBKBCASP1 | |
| SCHEMBL594370 | 0.87 | FOLH1 (0.59) | TTRALDH1A1PTPRCCYP2C8CYP2C9 | |
| SCHEMBL4049678 | 0.86 | BCAT2 (0.49) | BCAT2DHODHTTRALDH1A1PTPRC | |
| SCHEMBL22729968 | 0.85 | TTR (0.52) | TTRALDH1A1PTPRCCYP2C8CYP2C9 | |
| SCHEMBL29562805 | 0.85 | TTR (0.52) | TTRALDH1A1PTPRCCYP2C8CYP2C9 | |
| Water SCHEMBL28745832 | 0.85 | FOLH1 (0.57) | TTRALDH1A1PTPRCCYP2C8CYP2C9 | |
| SCHEMBL27736136 | 0.82 | CYP2C8 (0.71) | TTRALDH1A1CYP2C8CYP2C9KDM4E | |
| SCHEMBL3104353 | 0.82 | KDM4C (0.53) | TTRALDH1A1PTPRCCYP2C8CYP2C9 | |
| SCHEMBL6175390 | 0.81 | CYP1A2 (0.57) | BCAT2PLA2G2AALDH1A1FOLH1IKBKB | |
| SCHEMBL28791455 | 0.81 | CYP2C8 (0.50) | TTRALDH1A1PTPRCCYP2C8CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778658-A2 | MODULATORS OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS AND THERAPEUTIC USES THEREOF | Siena Biotech S.p.A. (IT) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006008133-A2 | MODULATORS OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS AND THERAPEUTIC USES THEREOF | SIENA BIOTECH S.P.A. (IT) | 2006-01-26 | — | — | WO | disclosed |