SCHEMBL5215277

SCHEMBL5215277

CC(C)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C1CCC(=O)C1

nearest known ligand 0.40

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 15/20 0.40
PTGDR2 Q9Y5Y4 1/20 0.38
BMP1 P13497 1/20 0.35
EPHX1 P07099 1/20 0.35
KDM4E B2RXH2 1/20 0.35
APAF1 O14727 1/20 0.35
TSHR P16473 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
HSD17B10 Q99714 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5212179 0.87 TACR1 (0.37) TACR1PTGDR2
SCHEMBL6621794 0.84 TACR1 (0.49) TACR1
SCHEMBL6621807 0.84 TACR1 (0.39) TACR1
SCHEMBL6620267 0.78 UBE2M (0.36) TACR1
SCHEMBL5729938 0.72 CCR2 (0.49) TACR1KDM4ETSHRNPSR1
SCHEMBL6957247 0.70 HTT (0.47) TACR1
SCHEMBL20568328 0.66 TACR1 (0.43) TACR1BMP1EPHX1
SCHEMBL14307849 0.64 TACR1 (0.44) TACR1BMP1
SCHEMBL6965223 0.64 HTT (0.51) TACR1
SCHEMBL14169881 0.63 CCR2 (0.40) TACR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1558599-A4 HETEROARYLPIPERIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO INC (US) 2007-06-27 EP disclosed
EP-1558599-A2 HETEROARYLPIPERIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Merck & Co., Inc. (US) 2005-08-03 EP disclosed
EP-1318811-A4 CYCLOPENTYL MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO INC (US) 2004-07-14 EP disclosed
WO-2004041777-A2 HETEROARYLPIPERIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO., INC. (US) 2004-05-21 WO disclosed
EP-1318811-A1 CYCLOPENTYL MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Merck & Co., Inc. (US) 2003-06-18 EP disclosed
WO-2002013824-A1 CYCLOPENTYL MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO., INC. (US) 2002-02-21 WO disclosed