Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL526662 | 0.85 | SMN1; SMN2 (0.58) | ALDH1A1MEN1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL5216279 | 0.85 | LMNA (0.54) | ALDH1A1LMNAMAPTSMN1; SMN2NPC1 | |
| Acetic Acid SCHEMBL25348402 | 0.84 | KDM4E (0.49) | ALDH1A1MEN1LMNAMAPTALOX12 | |
| SCHEMBL9013254 | 0.83 | MEN1 (0.50) | ALDH1A1MEN1LMNAMAPTALOX12 | |
| SCHEMBL6331530 | 0.83 | SMN1; SMN2 (0.46) | ALDH1A1MEN1LMNAMAPTALOX12 | |
| SCHEMBL5223686 | 0.83 | SMN1; SMN2 (0.62) | ALDH1A1MEN1MAPTRECQLKMT2A | |
| Hydrochloric Acid SCHEMBL5219486 | 0.82 | MAPT (0.51) | MEN1LMNAMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL6957332 | 0.80 | RAB9A (0.50) | ALDH1A1MEN1LMNAMAPTKMT2A | |
| Propionic Acid SCHEMBL27527775 | 0.80 | CXCL8 (0.51) | ALDH1A1MEN1LMNAMAPTALOX12 | |
| SCHEMBL11245998 | 0.79 | SMN1; SMN2 (0.54) | ALDH1A1KMT2ASMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-55115868-A | — | — | None | — | — | JP | disclosed |
| EP-1458386-B1 | AROYL PYRROLE HETEROERYL AND METHANOLS USEFUL FOR TREATING A CENTRAL NERVOUS SYSTEM DISORDER | ORTHO MCNEIL PHARM INC (US) | 2007-04-18 | — | — | EP | disclosed |
| US-20050148636-A1 | Useful aroyl pyrrole heteroaryl methanones and methanols | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-07-07 | — | — | US | disclosed |
| US-6897319-B2 | Useful aroyl pyrrole heteroaryl methanones and methanols | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2005-05-24 | — | — | US | disclosed |
| EP-1458386-A1 | AROYL PYRROLE HETEROERYL AND METHANOLS USEFUL FOR TREATING A CENTRAL NERVOUS SYSTEM DISORDER | Ortho-McNeil Pharmaceutical, Inc. (US) | 2004-09-22 | — | — | EP | disclosed |
| US-20040058980-A1 | Useful aroyl pyrrole heteroaryl methanones and methanols | ORTHO-MCNEIL PHARMACEUTICALS, INC. | 2004-03-25 | — | — | US | disclosed |
| US-20030181481-A1 | Useful aroyl pyrrole heteroaryl methanones and methanols | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-09-25 | — | — | US | disclosed |
| WO-2003057219-A1 | AROYL PYRROLE HETEROERYL AND METHANOLS USEFUL FOR TREATING A CENTRAL NERVOUS SYSTEM DISORDER | ORTHO-MCNEIL PHARMACEUTICAL INC. (US) | 2003-07-17 | — | — | WO | disclosed |
| WO-2003057147-A2 | USEFUL AROYL PYRROLE HETEROARYL METHANONES AND METHANOLS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-07-17 | — | — | WO | disclosed |
| WO-1995013266-A1 | ACYLPYRROLE-ALKANOIC ACIDS AND INDOLE-2-ALKANOIC ACIDS PLUS THEIR DERIVATIVES FOR USE AS INHIBITORS OF PHOSPHOLIPASE A¿2? | MERCKLE GMBH CHEM.-PHARM. FABRIK (DE) | 1995-05-18 | — | — | WO | disclosed |
| EP-0231996-B1 | NOVEL AMINO ACID DERIVATIVES | NOVO NORDISK A/S (DK) | 1993-10-06 | — | — | EP | disclosed |
| US-4931450-A | Amino acid derivatives | NOVO INDUSTRI A/S (DK) | 1990-06-05 | — | — | US | disclosed |
| EP-0231996-A2 | Novel amino acid derivatives | NOVO NORDISK A/S (DK) | 1987-08-12 | — | — | EP | disclosed |
| JP-S55115868-A | BETA,BETA,BETA-TRIHALO-ALPHA-HYDROXYETHYL SUBSTITUTED-2-AROYL PYRROLE DERIVATIVE | SAGAMI CHEM RES CENTER | 1980-09-06 | — | — | JP | disclosed |
| US-4002643-A | REARRANGING WITH A STRONG, ANHYDROUS, NON-OXIDIZING ACID | MCNEIL LABORATORIES, INC. (US) | 1977-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050148636-A1 | Useful aroyl pyrrole heteroaryl methanones and methanols | CYP11B2, NLN, CNR2 | ALDH1A1 1382/4885MEN1 706/4885LMNA 3871/4885 |
| US-20040058980-A1 | Useful aroyl pyrrole heteroaryl methanones and methanols | CYP11B2, NLN, CNR2 | ALDH1A1 1382/4885MEN1 706/4885LMNA 3871/4885 |
| US-20030181481-A1 | Useful aroyl pyrrole heteroaryl methanones and methanols | CYP11B2, NLN, CNR2 | ALDH1A1 1382/4885MEN1 706/4885LMNA 3871/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.