Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 7/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.43 |
| ▸ | IGF1R | P08069 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | LOX | P28300 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5214698 | 0.77 | DHFR (0.63) | DHFRIGF1R | |
| SCHEMBL5212593 | 0.75 | DHFR (0.65) | DHFR | |
| SCHEMBL8263971 | 0.74 | BACE1 (0.54) | IGF1R | |
| SCHEMBL6489092 | 0.72 | CSNK2A1 (0.54) | LOXLOXL2HRH1 | |
| SCHEMBL12696907 | 0.71 | LOX (0.55) | LOXLOXL2HRH1 | |
| SCHEMBL7499087 | 0.70 | LTA4H (0.43) | ROCK1 | |
| SCHEMBL20190549 | 0.70 | TAAR1 (0.56) | HRH1 | |
| SCHEMBL1409246 | 0.70 | CSNK2A1 (0.50) | LOXLOXL2HRH1 | |
| SCHEMBL676340 | 0.70 | ALDH1A1 (0.45) | KCNH2HRH1 | |
| SCHEMBL13802801 | 0.70 | HRH1 (0.46) | KCNH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831170-A1 | SUBSTITUTED AMINOPYRIDINES AND USES THEREOF | AstraZeneca AB (SE) | 2007-09-12 | — | — | EP | claimed |
| WO-2006065204-A1 | SUBSTITUTED AMINOPYRIDINES AND USES THEREOF | ASTRAZENECA AB (SE) | 2006-06-22 | — | — | WO | claimed |