Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 2/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5214956 | 0.82 | CCR5 (0.52) | LTA4HMAPK14PTGER1 | |
| SCHEMBL5215267 | 0.78 | ABCB1 (0.47) | — | |
| SCHEMBL5244112 | 0.77 | CYP11B1 (0.52) | LTA4HMAPK14 | |
| SCHEMBL8264992 | 0.77 | BACE1 (0.60) | LTA4HMAPK14MRGPRX4MRGPRX1 | |
| SCHEMBL20147117 | 0.76 | MRGPRX4 (0.53) | MRGPRX4RXRARXRBRXRGPTGER1 | |
| SCHEMBL769497 | 0.75 | RXRA (0.50) | MRGPRX4RXRARXRBRXRGPTGER1 | |
| SCHEMBL768907 | 0.75 | MRGPRX4 (0.52) | MRGPRX4RXRARXRBRXRGELANE | |
| SCHEMBL5247113 | 0.74 | BACE1 (0.67) | LTA4HMAPK14ALOX5AP | |
| SCHEMBL19483249 | 0.73 | MRGPRX4 (0.55) | MRGPRX4RXRARXRBRXRG | |
| SCHEMBL784604 | 0.72 | MRGPRX4 (0.46) | MRGPRX4RXRARXRBRXRGPTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831170-A1 | SUBSTITUTED AMINOPYRIDINES AND USES THEREOF | AstraZeneca AB (SE) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006065204-A1 | SUBSTITUTED AMINOPYRIDINES AND USES THEREOF | ASTRAZENECA AB (SE) | 2006-06-22 | — | — | WO | disclosed |