Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.67 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8264955 | 0.80 | BACE1 (1.00) | BACE1TNK2LTA4HMAPK14ADORA2A | |
| SCHEMBL5244112 | 0.80 | CYP11B1 (0.52) | BACE1LTA4HMAPK14 | |
| SCHEMBL5215267 | 0.78 | ABCB1 (0.47) | BACE1 | |
| SCHEMBL5214956 | 0.77 | CCR5 (0.52) | LTA4HMAPK14 | |
| SCHEMBL5215584 | 0.74 | LTA4H (0.45) | LTA4HMAPK14ALOX5AP | |
| SCHEMBL8265056 | 0.74 | BACE1 (0.88) | BACE1TNK2LTA4HMAPK14 | |
| SCHEMBL8265032 | 0.72 | BACE1 (0.85) | BACE1 | |
| SCHEMBL4934023 | 0.72 | BACE1 (0.52) | BACE1TNK2ADORA2AADORA1ENPP2 | |
| SCHEMBL8265066 | 0.70 | BACE1 (1.00) | BACE1TNK2 | |
| SCHEMBL6669227 | 0.69 | ENPP2 (0.48) | BACE1ADORA2AENPP2ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831170-A1 | SUBSTITUTED AMINOPYRIDINES AND USES THEREOF | AstraZeneca AB (SE) | 2007-09-12 | — | — | EP | claimed |
| WO-2006065204-A1 | SUBSTITUTED AMINOPYRIDINES AND USES THEREOF | ASTRAZENECA AB (SE) | 2006-06-22 | — | — | WO | claimed |