Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.49 |
| ▸ | CYP17A1 | P05093 | 4/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.45 |
| ▸ | PRKCI | P41743 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | CTSA | P10619 | 2/20 | 0.43 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5888495 | 1.00 | KIF11 (0.49) | KIF11CYP17A1PSEN1PSEN2APH1B | |
| SCHEMBL84433 | 0.85 | RXRA (0.54) | KIF11CYP17A1PSEN1PSEN2APH1B | |
| SCHEMBL1252080 | 0.84 | RXRA (0.49) | CTSLCTSSCTSKLMNARXRA | |
| SCHEMBL10145754 | 0.84 | RXRA (0.49) | CTSLCTSSCTSKLMNARXRA | |
| SCHEMBL5218298 | 0.82 | MKNK1 (0.56) | CYP17A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5848606 | 0.82 | MKNK1 (0.56) | CYP17A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5656094 | 0.80 | CTSK (0.46) | CTSKRXRARXRBRXRGIRAK4 | |
| SCHEMBL5888510 | 0.80 | CTSK (0.46) | CTSKRXRARXRBRXRGIRAK4 | |
| SCHEMBL17834279 | 0.79 | KIF11 (0.50) | KIF11CYP17A1PSEN1PSEN2APH1B | |
| SCHEMBL11203809 | 0.79 | RXRA (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2800565-A1 | CARBAMATE COMPOUNDS AND OF MAKING AND USING SAME | Abide Therapeutics, Inc. (US) | 2014-11-12 | — | — | EP | disclosed |
| EP-2739608-A1 | INSULIN SECRETION PROMOTING AGENTS | Centre Hospitalier de l'Université de Montréal (CA) | 2014-06-11 | — | — | EP | disclosed |
| WO-2013103973-A1 | CARBAMATE COMPOUNDS AND OF MAKING AND USING SAME | ABIDE THERAPEUTICS (US) | 2013-07-11 | — | — | WO | disclosed |
| WO-2013016807-A1 | INSULIN SECRETION PROMOTING AGENTS | CENTRE HOSPITALIER DE L'UNIVERSITE DE MONTREAL (CA) | 2013-02-07 | — | — | WO | disclosed |
| EP-1581516-A4 | 3-HETEROCYCLIC BENZYLAMIDE DERIVATIVES AS POTASSIUM CHANNEL OPENERS | BRISTOL MYERS SQUIBB CO (US) | 2007-10-17 | — | — | EP | disclosed |
| EP-1581516-A2 | 3-HETEROCYCLIC BENZYLAMIDE DERIVATIVES AS POTASSIUM CHANNEL OPENERS | Bristol-Myers Squibb Company (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004047744-A2 | 3-HETEROCYCLIC BENZYLAMIDE DERIVATIVES AS POTASSIUM CHANNEL OPENERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-06-10 | — | — | WO | disclosed |