Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 11/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5217026 | 0.91 | MAOB (0.42) | ABCB1MAOBKDM4EMEN1ALDH1A1 | |
| SCHEMBL5224566 | 0.84 | MAPK14 (0.47) | TAAR1MAOBHTR2CSLC6A4HTR2B | |
| SCHEMBL1154474 | 0.83 | CYP11B1 (0.43) | MEN1ALDH1A1KMT2A | |
| SCHEMBL5220371 | 0.82 | HTR2C (0.44) | TAAR1MAOBHTR2CSLC6A4HTR2B | |
| SCHEMBL5217387 | 0.81 | CASR (0.41) | TAAR1MAOBMEN1ALDH1A1KMT2A | |
| SCHEMBL5225071 | 0.81 | CASR (0.51) | SLC6A4 | |
| SCHEMBL5222695 | 0.80 | MAPK14 (0.40) | DRD2HTR2CSLC6A4HTR2BMEN1 | |
| SCHEMBL1154302 | 0.79 | LMNA (0.43) | TAAR1DRD2MAOBKMT2ATDP1 | |
| SCHEMBL5221531 | 0.79 | CASR (0.41) | TAAR1HTR1ASLC6A4 | |
| SCHEMBL22169493 | 0.77 | RAB9A (0.47) | MAOBKDM4EMEN1KMT2ASQOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765810-A1 | 2,4-DIAMINOQUINAZOLINES FOR SPINAL MUSCULAR ATROPHY | Decode Chemistry, Inc. (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005123724-A1 | 2,4-DIAMINOQUINAZOLINES FOR SPINAL MUSCULAR ATROPHY | DECODE CHEMISTRY, INC. (US) | 2005-12-29 | — | — | WO | disclosed |