Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | MPO | P05164 | 1/20 | 0.34 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.34 |
| ▸ | FASN | P49327 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | TEK | Q02763 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5211776 | 0.90 | PIK3CD (0.45) | PIK3CDMPOCYSLTR1PKMTEK | |
| SCHEMBL5215860 | 0.81 | PIK3CD (0.44) | PIK3CDMPOCYSLTR1PKM | |
| SCHEMBL5215051 | 0.80 | PIK3CD (0.43) | PIK3CDMPOCYSLTR1PKM | |
| SCHEMBL5212891 | 0.80 | PIK3CD (0.47) | PIK3CDMPOCYSLTR1PKMMEN1 | |
| SCHEMBL5217976 | 0.79 | GCGR (0.37) | PIK3CDMPOCYSLTR1PKM | |
| SCHEMBL4762850 | 0.78 | PDE4A (0.35) | PIK3CDPGRNR3C2FASN | |
| SCHEMBL5218139 | 0.76 | PIK3CD (0.43) | PIK3CDMPOCYSLTR1PKMKDR | |
| SCHEMBL5212507 | 0.76 | PIK3CD (0.43) | PIK3CDPGRMPOCYSLTR1PKM | |
| SCHEMBL5211464 | 0.75 | PIK3CD (0.42) | PIK3CDMPOCYSLTR1PKM | |
| SCHEMBL5212435 | 0.74 | PIK3CD (0.42) | PIK3CDMPOCYSLTR1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636213-B1 | 3-ARYLOXY AND 3-HETEROARYLOXY SUBSTITUTED BENZO(B) THIOPHENES AS THERAPEUTIC AGENTS WITH PI3K ACTIVITY | WARNER LAMBERT CO (US) | 2007-06-13 | — | — | EP | claimed |