Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.38 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5701841 | 0.80 | KDM4E (0.42) | CHRNB4CHRNA3CHEK2HSP90AA1HSP90AB1 | |
| SCHEMBL6141526 | 0.78 | SSTR2 (0.39) | CHRNB4CHRNA3CHEK2MKNK1CHEK1 | |
| SCHEMBL2332409 | 0.76 | FDPS (0.60) | HPGDCHRNB4CHRNA3CHEK1HSP90AA1 | |
| SCHEMBL29038394 | 0.76 | FDPS (0.53) | HPGDCHRNB4CHRNA3CHEK1HSP90AA1 | |
| SCHEMBL11456190 | 0.76 | LTA4H (0.48) | CHRNA3 | |
| SCHEMBL6110644 | 0.74 | LTA4H (0.53) | CHEK2ERN1 | |
| SCHEMBL12491869 | 0.74 | CHRNB4 (0.39) | HPGDCHRNB4CHRNA3MKNK1CHEK1 | |
| SCHEMBL31256065 | 0.74 | CHRNB4 (0.47) | CHRNB4CHRNA3CHEK2 | |
| SCHEMBL11450540 | 0.74 | CHRNB4 (0.52) | CHRNB4CHRNA3 | |
| SCHEMBL5699880 | 0.73 | HPGD (0.65) | PTGDR2HPGDPLA2G1BATG4BERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831170-A1 | SUBSTITUTED AMINOPYRIDINES AND USES THEREOF | AstraZeneca AB (SE) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006065204-A1 | SUBSTITUTED AMINOPYRIDINES AND USES THEREOF | ASTRAZENECA AB (SE) | 2006-06-22 | — | — | WO | disclosed |