Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 2/20 | 0.45 |
| ▸ | KMO | O15229 | 1/20 | 0.44 |
| ▸ | NAPEPLD | Q6IQ20 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5453917 | 0.86 | PIK3CB (0.58) | PIK3CBALDH1A1KDM4EL3MBTL1PIK3CA | |
| SCHEMBL593003 | 0.84 | PIK3CB (0.48) | PIK3CBALDH1A1KDM4EPIK3CASMN1; SMN2 | |
| SCHEMBL7016486 | 0.80 | MEN1 (0.51) | PIK3CBALDH1A1KDM4EPIK3CASMN1; SMN2 | |
| SCHEMBL244072 | 0.80 | PIK3CA (0.47) | PIK3CBALDH1A1KDM4EPIK3CASMN1; SMN2 | |
| SCHEMBL29434078 | 0.80 | PIK3CA (0.47) | PIK3CBALDH1A1KDM4EPIK3CASMN1; SMN2 | |
| SCHEMBL1505634 | 0.80 | PIK3CB (0.47) | PIK3CBALDH1A1KDM4EPIK3CASMN1; SMN2 | |
| SCHEMBL27700148 | 0.78 | L3MBTL1 (0.46) | PIK3CBALDH1A1KDM4EL3MBTL1SMN1; SMN2 | |
| SCHEMBL987017 | 0.78 | HTT (0.65) | PIK3CBALDH1A1KDM4EPIK3CASMN1; SMN2 | |
| SCHEMBL24921343 | 0.77 | KMO (0.69) | PIK3CBALDH1A1KDM4EL3MBTL1PIK3CA | |
| SCHEMBL31706217 | 0.77 | KMO (0.69) | PIK3CBALDH1A1KDM4EL3MBTL1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070259849-A1 | Azine-Carboxamides as Anti-Cancer Agents | ASTRAZENECA AB (SE) | 2007-11-08 | — | — | US | disclosed |
| EP-1765790-A1 | AZINE-CARBOXAMIDES AS ANTI-CANCER AGENT | AstraZeneca AB (SE) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006003378-A1 | AZINE-CARBOXAMIDES AS ANTI-CANCER AGENT | ASTRAZENECA AB (SE) | 2006-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070259849-A1 | Azine-Carboxamides as Anti-Cancer Agents | ARAF, BRAF, RAF1 | PIK3CB 572/4885ALDH1A1 309/4885KDM4E 521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.