Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.31 |
| ▸ | TPMT | P51580 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5219833 | 0.88 | BACE1 (0.41) | GPR35POLBHCAR3GAAMEN1 | |
| SCHEMBL5219484 | 0.84 | BACE1 (0.44) | GPR35POLBHCAR3GAAMEN1 | |
| SCHEMBL5219825 | 0.76 | BACE1 (0.47) | GPR35POLBHCAR3GAACTSD | |
| SCHEMBL5218045 | 0.75 | CTSD (0.42) | HCAR3GAAMEN1KMT2ACTSD | |
| SCHEMBL5219490 | 0.73 | BACE1 (0.50) | POLBGAACTSDBACE1BACE2 | |
| SCHEMBL5218025 | 0.72 | BACE1 (0.41) | POLBGAAMEN1KMT2ACTSD | |
| SCHEMBL5220759 | 0.72 | BACE1 (0.45) | POLBHCAR3GAAMEN1KMT2A | |
| SCHEMBL5219772 | 0.71 | KDM4E (0.47) | GAAKMT2A | |
| SCHEMBL5219330 | 0.71 | POLB (0.30) | POLB | |
| SCHEMBL5224501 | 0.70 | POLB (0.36) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |