Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 6/20 | 0.45 |
| ▸ | BACE2 | Q9Y5Z0 | 5/20 | 0.45 |
| ▸ | CTSD | P07339 | 4/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | PLEC | Q15149 | 1/20 | 0.34 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5218045 | 0.97 | CTSD (0.42) | BACE1BACE2CTSDPDE4BPDE4D | |
| SCHEMBL5218055 | 0.91 | CTSD (0.44) | BACE1BACE2CTSDPDE4BPDE4D | |
| SCHEMBL5220748 | 0.89 | BACE1 (0.52) | BACE1BACE2CTSDPDE4BPDE4D | |
| SCHEMBL5222641 | 0.88 | CTSD (0.41) | BACE1BACE2CTSDPDE4BPDE4D | |
| SCHEMBL5218053 | 0.86 | CTSD (0.49) | BACE1BACE2CTSDPDE4BPDE4D | |
| SCHEMBL5219484 | 0.85 | BACE1 (0.44) | BACE1BACE2CTSDGAAMAPT | |
| SCHEMBL5218643 | 0.83 | DRD2 (0.35) | BACE1BACE2CTSDPOLBSMN1; SMN2 | |
| SCHEMBL5219833 | 0.82 | BACE1 (0.41) | BACE1BACE2CTSDPDE4BPDE4D | |
| SCHEMBL5218051 | 0.80 | BACE1 (0.51) | BACE1BACE2CTSDPDE4BPDE4D | |
| SCHEMBL5218025 | 0.79 | BACE1 (0.41) | BACE1BACE2CTSDPDE4BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |