Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 2/20 | 0.67 |
| ▸ | PYGL | P06737 | 1/20 | 0.64 |
| ▸ | F7 | P08709 | 1/20 | 0.58 |
| ▸ | F3 | P13726 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | MITF | O75030 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.53 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.53 |
| ▸ | GABRP | O00591 | 2/20 | 0.53 |
| ▸ | GABRD | O14764 | 2/20 | 0.53 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.53 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.53 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.53 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.53 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9368560 | 0.90 | NR4A2 (0.67) | NR4A2PYGLF7F3MEN1 | |
| SCHEMBL8260360 | 0.84 | NOTUM (0.53) | NR4A2MEN1MITFLMNAMAPT | |
| SCHEMBL5225716 | 0.84 | NR4A2 (0.67) | NR4A2MEN1MITFLMNAMAPT | |
| SCHEMBL2807419 | 0.83 | GPR84 (0.54) | NR4A2MEN1MITFLMNAMAPT | |
| SCHEMBL5063303 | 0.82 | PYGL (0.56) | NR4A2PYGLF7F3MEN1 | |
| SCHEMBL5222563 | 0.82 | F7 (0.52) | NR4A2PYGLF7F3MEN1 | |
| SCHEMBL5222554 | 0.81 | CTNNB1 (0.71) | NR4A2MEN1LMNAMAPTRAB9A | |
| SCHEMBL16765425 | 0.81 | NR4A2 (0.61) | NR4A2PYGLF7F3LMNA | |
| SCHEMBL9789068 | 0.80 | F7 (0.69) | NR4A2PYGLF7F3MEN1 | |
| SCHEMBL4242189 | 0.80 | NR4A2 (1.00) | NR4A2PYGLF7F3GABRP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1618094-B1 | SUBSTITUTED HETEROARYLS AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES | INST FOR PHARM DISCOVERY INC (US) | 2007-09-05 | — | — | EP | disclosed |
| EP-1618094-A1 | SUBSTITUTED HETEROARYLS AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES | The Institutes for Pharmaceutical Discovery, LLC (US) | 2006-01-25 | — | — | EP | disclosed |
| US-20050009817-A1 | Substituted heteroaryls | INSTITUTES FOR PHARMACEUTICAL DISCOVERY, L.L.C. | 2005-01-13 | — | — | US | disclosed |
| WO-2004099159-A1 | SUBSTITUTED HETEROARYLS AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2004-11-18 | — | — | WO | disclosed |
| EP-0516849-B1 | INDOLE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-01-25 | — | — | EP | disclosed |
| US-5283251-A | Testosterone 5a-reductase inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-02-01 | — | — | US | disclosed |
| EP-0516849-A1 | INDOLE DERIVATIVES. | FUJISAWA PHARMACEUTICAL CO (JP) | 1992-12-09 | — | — | EP | disclosed |
| WO-1991013060-A1 | INDOLE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-09-05 | — | — | WO | disclosed |
| CN-1054250-A | INDOLE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO (JP) | 1991-09-04 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009817-A1 | Substituted heteroaryls | PTPRS, PTPRO, PTPRR | NR4A2 4086/4885PYGL 63/4885F7 4714/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.