Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.61 |
| ▸ | PYGL | P06737 | 1/20 | 0.59 |
| ▸ | F7 | P08709 | 1/20 | 0.57 |
| ▸ | F3 | P13726 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | GABRP | O00591 | 1/20 | 0.49 |
| ▸ | GABRD | O14764 | 1/20 | 0.49 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.49 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.49 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.49 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.49 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.49 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.49 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.49 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.49 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.49 |
| ▸ | GABRE | P78334 | 1/20 | 0.49 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.49 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5309810 | 0.84 | NR4A2 (0.72) | NR4A2PYGLF7F3GABRA1 | |
| SCHEMBL9789068 | 0.82 | F7 (0.69) | NR4A2PYGLF7F3LMNA | |
| SCHEMBL404854 | 0.82 | NR4A2 (0.60) | NR4A2PYGLF7F3GABRP | |
| SCHEMBL4813460 | 0.81 | PKM (0.62) | NR4A2LMNARAB9A | |
| SCHEMBL15245934 | 0.81 | F7 (0.71) | NR4A2PYGLF7F3LMNA | |
| SCHEMBL5220143 | 0.81 | NR4A2 (0.67) | NR4A2PYGLF7F3LMNA | |
| SCHEMBL21808836 | 0.79 | PKM (0.67) | NR4A2F7F3LMNATSHR | |
| SCHEMBL3443344 | 0.79 | F7 (0.73) | NR4A2PYGLF7F3LMNA | |
| SCHEMBL29492466 | 0.79 | F7 (0.68) | NR4A2PYGLF7F3GABRP | |
| SCHEMBL1366633 | 0.78 | GABRA1 (0.74) | NR4A2GABRA1GABRB1GABRA3GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2800748-B1 | CYCLIC AMIDE DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE AND USES THEREOF | CONNEXIOS LIFE SCIENCES PVT LTD (IN) | 2017-03-29 | — | — | EP | disclosed |
| EP-2800748-B1 | CYCLIC AMIDE DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE AND USES THEREOF | CONNEXIOS LIFE SCIENCES PVT LTD (IN) | 2017-03-29 | — | — | EP | disclosed |
| US-9453014-B2 | Cyclic amide derivatives as inhibitors of 11-β-hydroxysteroid dehydrogenase and uses thereof | CONNEXIOS LIFE SCIENCES PVT. LTD. (IN) | 2016-09-27 | — | — | US | disclosed |
| US-9453014-B2 | Cyclic amide derivatives as inhibitors of 11-β-hydroxysteroid dehydrogenase and uses thereof | CONNEXIOS LIFE SCIENCES PVT. LTD. (IN) | 2016-09-27 | — | — | US | disclosed |
| US-9453014-B2 | Cyclic amide derivatives as inhibitors of 11-β-hydroxysteroid dehydrogenase and uses thereof | CONNEXIOS LIFE SCIENCES PVT. LTD. (IN) | 2016-09-27 | — | — | US | disclosed |
| US-20150158860-A1 | CYCLIC AMIDE DERIVATIVES AS INHIBITORS OF 11 - BETA - HYDROXYSTEROID DEHYDROGENASE AND USES THEREOF | CONNEXIOS LIFE SCIENCES PVT. LTD. (IN) | 2015-06-11 | — | — | US | disclosed |
| US-20150158860-A1 | CYCLIC AMIDE DERIVATIVES AS INHIBITORS OF 11 - BETA - HYDROXYSTEROID DEHYDROGENASE AND USES THEREOF | CONNEXIOS LIFE SCIENCES PVT. LTD. (IN) | 2015-06-11 | — | — | US | disclosed |
| US-20150158860-A1 | CYCLIC AMIDE DERIVATIVES AS INHIBITORS OF 11 - BETA - HYDROXYSTEROID DEHYDROGENASE AND USES THEREOF | CONNEXIOS LIFE SCIENCES PVT. LTD. (IN) | 2015-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150158860-A1 | CYCLIC AMIDE DERIVATIVES AS INHIBITORS OF 11 - BETA - HYDROXYSTEROID DEHYDROGENASE AND USES THEREOF | HSD11B1, HSD11B2, HSD17B1 | NR4A2 1801/4885PYGL 213/4885F7 4489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.