Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31388082 | 1.00 | ALDH1A1 (0.45) | ALDH1A1USP2KDM4ECREBBPNPC1 | |
| SCHEMBL11171580 | 0.88 | KDM4E (0.50) | ALDH1A1KDM4ECREBBPNPC1RAB9A | |
| SCHEMBL3176817 | 0.88 | KDM4E (0.54) | ALDH1A1USP2KDM4ECREBBPNPC1 | |
| SCHEMBL2381523 | 0.87 | NPC1 (0.57) | USP2CREBBPNPC1TP53RAB9A | |
| SCHEMBL28995855 | 0.83 | PARP10 (0.54) | ALDH1A1USP2KDM4ECREBBPCA12 | |
| SCHEMBL9168136 | 0.83 | PLA2G2A (0.57) | ALDH1A1NPC1TP53RAB9AMAPT | |
| SCHEMBL28995925 | 0.83 | PLA2G2A (0.51) | USP2CREBBPNPC1TP53RAB9A | |
| SCHEMBL414382 | 0.82 | CA1 (0.52) | ALDH1A1USP2KDM4ENPC1TP53 | |
| SCHEMBL26032282 | 0.81 | MAOA (0.43) | ALDH1A1USP2KDM4ECA12CA1 | |
| SCHEMBL713400 | 0.81 | CA12 (0.63) | ALDH1A1KDM4ECREBBPNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116082181-A | Method for preparing 3-amino-5-ethoxy-benzoic acid | 爱斯特（成都）生物制药股份有限公司 | 2023-05-09 | — | — | CN | disclosed |
| US-9522911-B2 | Crystalline forms of tricyclic compound acid salt or hydrate thereof, and method for making thereof | JEIL PHARMACEUTICAL CO., LTD. (KR) | 2016-12-20 | — | — | US | disclosed |
| US-9522911-B2 | Crystalline forms of tricyclic compound acid salt or hydrate thereof, and method for making thereof | JEIL PHARMACEUTICAL CO., LTD. (KR) | 2016-12-20 | — | — | US | disclosed |
| US-9522911-B2 | Crystalline forms of tricyclic compound acid salt or hydrate thereof, and method for making thereof | JEIL PHARMACEUTICAL CO., LTD. (KR) | 2016-12-20 | — | — | US | disclosed |
| US-20140350007-A1 | CRYSTALLINE FORMS OF TRICYCLIC COMPOUND ACID SALT OR HYDRATE THEREOF, AND METHOD FOR MAKING THEREOF | JEIL PHARMACEUTICAL CO., LTD. (KR) | 2014-11-27 | — | — | US | disclosed |
| US-20140350007-A1 | CRYSTALLINE FORMS OF TRICYCLIC COMPOUND ACID SALT OR HYDRATE THEREOF, AND METHOD FOR MAKING THEREOF | JEIL PHARMACEUTICAL CO., LTD. (KR) | 2014-11-27 | — | — | US | disclosed |
| US-20140350007-A1 | CRYSTALLINE FORMS OF TRICYCLIC COMPOUND ACID SALT OR HYDRATE THEREOF, AND METHOD FOR MAKING THEREOF | JEIL PHARMACEUTICAL CO., LTD. (KR) | 2014-11-27 | — | — | US | disclosed |
| US-7253198-B2 | Hydroxyethylamine derivatives for the treatment of Alzheimer's disease | GLAXO GROUP LIMITED (GB) | 2007-08-07 | — | — | US | disclosed |
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |
| US-20060211740-A1 | Novel compounds | GLAXO GROUP LIMITED | 2006-09-21 | — | — | US | disclosed |
| US-20060025459-A1 | Hydroxyethylamine derivatives for the treatment of alzheimer's disease | GLAXO GROUP LIMITED (GB) | 2006-02-02 | — | — | US | disclosed |
| EP-1611089-A2 | HYDROXYETHYLAMINE COMPOUNDS HAVING ASP2 INHIBITORY ACTIVITY FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LIMITED (GB) | 2006-01-04 | — | — | EP | disclosed |
| EP-1567488-A1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LIMITED (GB) | 2005-08-31 | — | — | EP | disclosed |
| WO-2004080376-A2 | HYDROXYETHYLAMINE COMPOUNDS HAVING ASP2 INHIBITORY ACTIVITY FOR THE TREATMENT OF ALZHEIMER’S DISEASE | GLAXO GROUP LIMITED (GB) | 2004-09-23 | — | — | WO | disclosed |
| WO-2004050619-A1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LIMITED (GB) | 2004-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060025459-A1 | Hydroxyethylamine derivatives for the treatment of alzheimer's disease | BACE2, PSEN2, BACE1 | ALDH1A1 3102/4885USP2 508/4885KDM4E 1129/4885 |
| US-20060211740-A1 | Novel compounds | BACE2, BACE1, PSEN2 | ALDH1A1 4018/4885USP2 650/4885KDM4E 1890/4885 |
| US-20140350007-A1 | CRYSTALLINE FORMS OF TRICYCLIC COMPOUND ACID SALT OR HYDRATE THEREOF, AND METHOD FOR MAKING THEREOF | CTSA, HTT, HIF1AN | ALDH1A1 1148/4885USP2 3957/4885KDM4E 4329/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.