Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.66 |
| ▸ | PSMB11 | A5LHX3 | 6/20 | 0.49 |
| ▸ | PSMA7 | O14818 | 6/20 | 0.49 |
| ▸ | PSMB1 | P20618 | 6/20 | 0.49 |
| ▸ | PSMA1 | P25786 | 6/20 | 0.49 |
| ▸ | PSMA2 | P25787 | 6/20 | 0.49 |
| ▸ | PSMA3 | P25788 | 6/20 | 0.49 |
| ▸ | PSMA4 | P25789 | 6/20 | 0.49 |
| ▸ | PSMB8 | P28062 | 6/20 | 0.49 |
| ▸ | PSMB9 | P28065 | 6/20 | 0.49 |
| ▸ | PSMA5 | P28066 | 6/20 | 0.49 |
| ▸ | PSMB4 | P28070 | 6/20 | 0.49 |
| ▸ | PSMB6 | P28072 | 6/20 | 0.49 |
| ▸ | PSMB5 | P28074 | 6/20 | 0.49 |
| ▸ | PSMB10 | P40306 | 6/20 | 0.49 |
| ▸ | PSMB3 | P49720 | 6/20 | 0.49 |
| ▸ | PSMB2 | P49721 | 6/20 | 0.49 |
| ▸ | PSMA6 | P60900 | 6/20 | 0.49 |
| ▸ | PSMA8 | Q8TAA3 | 6/20 | 0.49 |
| ▸ | PSMB7 | Q99436 | 6/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11832781 | 0.83 | CES2 (0.66) | CES2PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL24209801 | 0.83 | ALDH1A1 (0.53) | CES2ATMALDH1A1KDM4EHPGD | |
| SCHEMBL13753088 | 0.82 | CES2 (0.60) | CES2PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL24073216 | 0.81 | ALDH1A1 (0.62) | CES2ALDH1A1KDM4EHPGDNPSR1 | |
| Hydrochloric Acid SCHEMBL8393436 | 0.81 | CES2 (0.58) | CES2PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL2481244 | 0.81 | CES2 (0.58) | CES2PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL937701 | 0.80 | CES2 (0.72) | CES2PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL2856986 | 0.80 | CES2 (0.72) | CES2PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL13753149 | 0.80 | POLB (0.59) | CES2PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL10524850 | 0.79 | ALDH1A1 (0.61) | CES2ATMALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392219-A4 | SUBSTITUTED N'-(ARYLCARBONYL)-BENZHYDRAZIDES, N'-(ARYLCARBONYL)-BENZYLIDENE-HYDRAZIDES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOTOSIS AND THE USE THEREOF | CYTOVIA INC (US) | 2007-01-24 | — | — | EP | claimed |
| US-20040186078-A1 | Substituted N'-(arylcarbonyl)-benzhydrazides, N'-(arylcarbonyl)-benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. | 2004-09-23 | — | — | US | claimed |
| US-6716859-B2 | ANTICANCER AGENTS | CYTOVIA, INC. | 2004-04-06 | — | — | US | claimed |
| EP-1392219-A2 | SUBSTITUTED N'-(ARYLCARBONYL)-BENZHYDRAZIDES, N'-(ARYLCARBONYL)-BENZYLIDENE-HYDRAZIDES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOTOSIS AND THE USE THEREOF | Cytovia, Inc. (US) | 2004-03-03 | — | — | EP | claimed |
| US-20030013743-A1 | Substituted N'-(arylcarbonyl)-benzhydrazides, N'-(arylcarbonyl)-benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. | 2003-01-16 | — | — | US | claimed |
| WO-2002089745-A2 | SUBSTITUTED N'-(ARYLCARBONYL)-BENZHYDRAZIDES, N'-(ARYLCARBONYL)-BENZYLIDENE-HYDRAZIDES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2002-11-14 | — | — | WO | claimed |
| EP-1392219-A4 | SUBSTITUTED N'-(ARYLCARBONYL)-BENZHYDRAZIDES, N'-(ARYLCARBONYL)-BENZYLIDENE-HYDRAZIDES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOTOSIS AND THE USE THEREOF | CYTOVIA INC (US) | 2007-01-24 | — | — | EP | disclosed |
| US-7074813-B2 | Substituted N′-(arylcarbonyl)-benzhydrazides, N′-(arylcarbonyl)-benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. (US) | 2006-07-11 | — | — | US | disclosed |
| US-20040186078-A1 | Substituted N'-(arylcarbonyl)-benzhydrazides, N'-(arylcarbonyl)-benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. | 2004-09-23 | — | — | US | disclosed |
| US-6716859-B2 | ANTICANCER AGENTS | CYTOVIA, INC. | 2004-04-06 | — | — | US | disclosed |
| EP-1392219-A2 | SUBSTITUTED N'-(ARYLCARBONYL)-BENZHYDRAZIDES, N'-(ARYLCARBONYL)-BENZYLIDENE-HYDRAZIDES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOTOSIS AND THE USE THEREOF | Cytovia, Inc. (US) | 2004-03-03 | — | — | EP | disclosed |
| US-20030013743-A1 | Substituted N'-(arylcarbonyl)-benzhydrazides, N'-(arylcarbonyl)-benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. | 2003-01-16 | — | — | US | disclosed |
| WO-2002089745-A2 | SUBSTITUTED N'-(ARYLCARBONYL)-BENZHYDRAZIDES, N'-(ARYLCARBONYL)-BENZYLIDENE-HYDRAZIDES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2002-11-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040186078-A1 | Substituted N'-(arylcarbonyl)-benzhydrazides, N'-(arylcarbonyl)-benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof | CASP2, CASP1, BCL2 | CES2 3084/4885PSMB11 1895/4885PSMA7 2529/4885 |
| US-20030013743-A1 | Substituted N'-(arylcarbonyl)-benzhydrazides, N'-(arylcarbonyl)-benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof | CASP2, CASP1, BCL2 | CES2 3084/4885PSMB11 1895/4885PSMA7 2529/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.