Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | CACNA1G | O43497 | 6/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5227165 | 0.84 | CACNA1G (0.57) | MEN1KMT2AUSP2HTTCACNA1G | |
| SCHEMBL5224759 | 0.81 | CYP1A2 (0.48) | MEN1KMT2AHTTCYP1A2CYP2D6 | |
| SCHEMBL5223033 | 0.80 | MEN1 (0.47) | MEN1KMT2AUSP2HTTCYP1A2 | |
| SCHEMBL4866090 | 0.79 | MEN1 (0.49) | MEN1KMT2AUSP2HTTCYP1A2 | |
| SCHEMBL4865875 | 0.76 | MEN1 (0.49) | MEN1KMT2AUSP2HTTCYP1A2 | |
| SCHEMBL5220829 | 0.73 | CYP3A4 (0.53) | — | |
| SCHEMBL5223079 | 0.73 | CYP2D6 (0.48) | MEN1KMT2AHTTCYP2D6CACNA1G | |
| SCHEMBL5225645 | 0.73 | CYP1A2 (0.48) | MEN1KMT2AHTTCYP1A2CYP2D6 | |
| SCHEMBL6261178 | 0.72 | MEN1 (0.47) | MEN1KMT2AHTTCYP2D6CACNA1G | |
| SCHEMBL4862091 | 0.72 | MEN1 (0.49) | MEN1KMT2AUSP2HTTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1806346-A1 | Substituted piperazine compounds and their use as fatty acid oxidation inhibitors | CV THERAPEUTICS, INC. (US) | 2007-07-11 | — | — | EP | disclosed |
| EP-1567525-A2 | SUBSTITUTED PIPERAZINE COMPOUNDS AND THEIR USE AS FATTY ACID OXIDATION INHIBITORS | CV THERAPEUTICS, INC. (US) | 2005-08-31 | — | — | EP | disclosed |
| WO-2004052887-A2 | SUBSTITUTED PIPERAZINE COMPOUNDS AND THEIR USE AS FATTY ACID OXIDATION INHIBITORS | CV THERAPEUTICS, INC. (US) | 2004-06-24 | — | — | WO | disclosed |