Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | HRH1 | P35367 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | F8 | P00451 | 1/20 | 0.43 |
| ▸ | F5 | P12259 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5225645 | 0.91 | CYP1A2 (0.48) | MEN1KMT2AHTTCYP2D6CYP1A2 | |
| SCHEMBL5224759 | 0.83 | CYP1A2 (0.48) | MEN1KMT2AHTTCYP2D6CYP1A2 | |
| SCHEMBL5221069 | 0.80 | MEN1 (0.49) | MEN1KMT2AUSP2HTTCYP2D6 | |
| SCHEMBL6256607 | 0.80 | CYP2D6 (0.47) | MEN1KMT2AHTTCYP2D6MAPT | |
| SCHEMBL4861739 | 0.79 | CYP2D6 (0.58) | MEN1KMT2AUSP2HTTCYP2D6 | |
| SCHEMBL5228642 | 0.76 | CYP1A2 (0.47) | CYP1A2CYP3A4 | |
| SCHEMBL2332160 | 0.74 | LMNA (0.73) | MEN1KMT2AUSP2HTTCYP2D6 | |
| SCHEMBL6184593 | 0.73 | HRH1 (0.46) | MEN1KMT2AUSP2HTTCYP2D6 | |
| SCHEMBL4865613 | 0.71 | TSHR (0.48) | MEN1KMT2AUSP2CYP2D6CYP1A2 | |
| SCHEMBL6186218 | 0.71 | CACNA1G (0.52) | MEN1KMT2AHTTMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1806346-A1 | Substituted piperazine compounds and their use as fatty acid oxidation inhibitors | CV THERAPEUTICS, INC. (US) | 2007-07-11 | — | — | EP | disclosed |