Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.40 |
| ▸ | CTSD | P07339 | 3/20 | 0.33 |
| ▸ | BACE1 | P56817 | 3/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMO | O15229 | 1/20 | 0.32 |
| ▸ | STAT3 | P40763 | 4/20 | 0.32 |
| ▸ | CALCA | P06881 | 2/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.31 |
| ▸ | FEN1 | P39748 | 2/20 | 0.31 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.31 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.31 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.31 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.31 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5259082 | 0.88 | ACMSD (0.40) | POLBACMSDKMOSTAT3 | |
| SCHEMBL5219461 | 0.86 | CTSD (0.36) | POLBCTSDBACE1BACE2CYP3A4 | |
| SCHEMBL5219217 | 0.77 | CTSD (0.35) | POLBCTSDBACE1BACE2CYP3A4 | |
| SCHEMBL5218901 | 0.75 | BACE1 (0.40) | POLBCTSDBACE1BACE2CYP3A4 | |
| SCHEMBL5221196 | 0.75 | CTSD (0.42) | POLBCTSDBACE1BACE2CYP3A4 | |
| SCHEMBL5219458 | 0.75 | OPRK1 (0.34) | STAT3 | |
| SCHEMBL5220634 | 0.74 | BACE1 (0.52) | POLBCTSDBACE1BACE2CYP3A4 | |
| SCHEMBL5222292 | 0.74 | POLB (0.59) | POLBCTSDBACE1BACE2KMO | |
| SCHEMBL5222900 | 0.71 | CTSD (0.37) | POLBCTSDBACE1BACE2CYP3A4 | |
| SCHEMBL5218765 | 0.71 | CTSD (0.34) | POLBCTSDBACE1BACE2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |