Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.31 |
| ▸ | RARB | P10826 | 2/20 | 0.30 |
| ▸ | RARA | P10276 | 1/20 | 0.30 |
| ▸ | RARG | P13631 | 1/20 | 0.30 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5218910 | 0.96 | MCL1 (0.34) | MCL1METAP2RARBRARARARG | |
| SCHEMBL5222900 | 0.88 | CTSD (0.37) | MCL1RARBRARARARG | |
| SCHEMBL5218901 | 0.85 | BACE1 (0.40) | MCL1 | |
| SCHEMBL5223868 | 0.84 | CTSD (0.34) | DRD2 | |
| SCHEMBL5223182 | 0.82 | BACE1 (0.40) | — | |
| SCHEMBL5220629 | 0.79 | BACE1 (0.43) | — | |
| SCHEMBL5221018 | 0.77 | MRGPRX4 (0.30) | — | |
| SCHEMBL5221777 | 0.76 | ALDH1A1 (0.40) | — | |
| SCHEMBL5221190 | 0.73 | CTSD (0.34) | — | |
| SCHEMBL5223859 | 0.73 | CTSD (0.42) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |