Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.47 |
| ▸ | BACE1 | P56817 | 8/20 | 0.39 |
| ▸ | BCHE | P06276 | 4/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.37 |
| ▸ | CTSD | P07339 | 2/20 | 0.37 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MME | P08473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5222213 | 1.00 | OPRM1 (0.47) | OPRM1BACE1BCHEATMMAPK1 | |
| SCHEMBL5223199 | 0.88 | LMNA (0.46) | OPRM1BACE1BCHEATMSLC6A11 | |
| SCHEMBL5223191 | 0.88 | LMNA (0.46) | OPRM1BACE1BCHEATMSLC6A11 | |
| SCHEMBL5219187 | 0.79 | SIGMAR1 (0.43) | OPRM1BACE1BCHEOPRK1OPRD1 | |
| SCHEMBL5219195 | 0.79 | SIGMAR1 (0.43) | OPRM1BACE1BCHEOPRK1OPRD1 | |
| SCHEMBL609658 | 0.78 | ANPEP (0.42) | OPRM1BACE1BCHEL3MBTL1OPRK1 | |
| SCHEMBL609656 | 0.78 | ANPEP (0.42) | OPRM1BACE1BCHEL3MBTL1OPRK1 | |
| SCHEMBL5219638 | 0.77 | ADRB3 (0.43) | OPRM1BACE1BCHEL3MBTL1OPRK1 | |
| SCHEMBL5218712 | 0.77 | OPRM1 (0.47) | OPRM1BACE1BCHEMAPK1L3MBTL1 | |
| SCHEMBL5219646 | 0.77 | ADRB3 (0.43) | OPRM1BACE1BCHEL3MBTL1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |