Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 3/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.30 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5226781 | 0.89 | SLC2A1 (0.40) | MAPK14SLC2A1AURKAKDRAURKB | |
| SCHEMBL5223855 | 0.76 | SLC2A1 (0.39) | MAPK14SLC2A1AURKAKDRAURKB | |
| SCHEMBL3442307 | 0.76 | MAPK14 (0.45) | MAPK14SLC2A1AURKAKDRAURKB | |
| SCHEMBL3434765 | 0.76 | ALDH1A2 (0.32) | — | |
| SCHEMBL5223920 | 0.76 | MAPK14 (0.37) | MAPK14SLC2A1AURKAKDRAURKB | |
| SCHEMBL5222821 | 0.76 | KDR (0.48) | SLC2A1AURKAKDRAURKBCDK19 | |
| SCHEMBL3442394 | 0.74 | SLC2A1 (0.54) | MAPK14SLC2A1AURKAKDRAURKB | |
| SCHEMBL3441817 | 0.72 | SLC2A1 (0.43) | MAPK14SLC2A1AURKAKDRAURKB | |
| SCHEMBL5226655 | 0.72 | SLC2A1 (0.40) | MAPK14SLC2A1AURKAKDRAURKB | |
| SCHEMBL5229411 | 0.70 | SLC2A1 (0.51) | SLC2A1AURKAKDRAURKBCDK19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828185-A2 | 2-PYRIMIDINYL PYRAZOLOPYRIDINE ERBB KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006068826-A2 | 2-PYRIMIDINYL PYRAZOLOPYRIDINE ERBB KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-06-29 | — | — | WO | disclosed |