Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 4/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.34 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.32 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 2/20 | 0.32 |
| ▸ | CDK2 | P24941 | 2/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5225154 | 0.88 | SLC2A1 (0.46) | MAPK14SLC2A1AURKBAURKAKDR | |
| SCHEMBL3442394 | 0.80 | SLC2A1 (0.54) | MAPK14SLC2A1AURKBAURKAKDR | |
| SCHEMBL3442307 | 0.80 | MAPK14 (0.45) | MAPK14SLC2A1AURKBAURKAKDR | |
| SCHEMBL5229307 | 0.78 | SLC2A1 (0.44) | MAPK14SLC2A1AURKBAURKAKDR | |
| SCHEMBL3441817 | 0.78 | SLC2A1 (0.43) | MAPK14SLC2A1AURKBAURKAKDR | |
| SCHEMBL5223864 | 0.76 | SLC2A1 (0.42) | MAPK14SLC2A1AURKBAURKAKDR | |
| SCHEMBL5223915 | 0.76 | MAPK14 (0.34) | MAPK14SLC2A1AURKBAURKAKDR | |
| SCHEMBL5222829 | 0.74 | SLC2A1 (0.53) | SLC2A1AURKBAURKAKDRCDK19 | |
| SCHEMBL5226662 | 0.74 | SLC2A1 (0.41) | MAPK14SLC2A1AURKBAURKAKDR | |
| SCHEMBL3434769 | 0.74 | BRAF (0.35) | AURKBSCN9ABRAFCDK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828185-A2 | 2-PYRIMIDINYL PYRAZOLOPYRIDINE ERBB KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006068826-A2 | 2-PYRIMIDINYL PYRAZOLOPYRIDINE ERBB KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-06-29 | — | — | WO | disclosed |