Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | NAAA | Q02083 | 2/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | REN | P00797 | 1/20 | 0.38 |
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 3/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5223916 | 1.00 | SIGMAR1 (0.41) | SIGMAR1BCHEHPGDCSNK1EOPRM1 | |
| SCHEMBL5224641 | 0.99 | CSNK1E (0.41) | SIGMAR1BCHEHPGDCSNK1EOPRM1 | |
| SCHEMBL5224655 | 0.99 | CSNK1E (0.41) | SIGMAR1BCHEHPGDCSNK1EOPRM1 | |
| SCHEMBL5220912 | 0.97 | REN (0.40) | BCHECSNK1EOPRM1OPRD1OPRK1 | |
| SCHEMBL5220920 | 0.97 | REN (0.40) | BCHECSNK1EOPRM1OPRD1OPRK1 | |
| SCHEMBL5219638 | 0.87 | ADRB3 (0.43) | BCHEOPRM1OPRD1OPRK1BACE1 | |
| SCHEMBL5219646 | 0.87 | ADRB3 (0.43) | BCHEOPRM1OPRD1OPRK1BACE1 | |
| SCHEMBL4516305 | 0.87 | REN (0.51) | RENMEN1KMT2A | |
| SCHEMBL4516309 | 0.87 | REN (0.51) | RENMEN1KMT2A | |
| SCHEMBL5216472 | 0.87 | BACE1 (0.43) | HPGDCSNK1EOPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |