Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.47 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5226503 | 0.91 | LMNA (0.46) | KMT2ASMN1; SMN2LMNAPOLBNR3C1 | |
| SCHEMBL5224173 | 0.82 | ALDH1A1 (0.52) | KMT2ASMN1; SMN2LMNAPOLBMAP4K1 | |
| SCHEMBL5224180 | 0.76 | SMN1; SMN2 (0.41) | KMT2ASMN1; SMN2LMNAPOLBMAP4K1 | |
| SCHEMBL31276556 | 0.73 | LMNA (0.58) | KMT2ALMNANR3C1NPSR1MAPT | |
| SCHEMBL11943538 | 0.72 | ALDH1A1 (0.62) | KMT2ASMN1; SMN2LMNAPOLBNPSR1 | |
| SCHEMBL11943535 | 0.71 | SMN1; SMN2 (0.53) | KMT2ASMN1; SMN2LMNAPOLBNPSR1 | |
| SCHEMBL5737789 | 0.71 | SMO (0.44) | LMNANR3C1MAPTALDH1A1MAPK14 | |
| SCHEMBL30108226 | 0.70 | MELK (0.60) | KMT2ASMN1; SMN2MAP4K1MAPTALDH1A1 | |
| SCHEMBL31276318 | 0.70 | PTGS2 (0.52) | KMT2ASMN1; SMN2LMNANR3C1NPSR1 | |
| SCHEMBL15779176 | 0.70 | PTGS2 (0.65) | KMT2ASMN1; SMN2LMNANR3C1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611122-B1 | SUBSTITUTED PYRAZOLE COMPOUNDS | MERCK PATENT GMBH (DE) | 2007-06-13 | — | — | EP | disclosed |