Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.45 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.40 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.40 |
| ▸ | MELK | Q14680 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5224110 | 0.91 | KMT2A (0.50) | LMNAPOLBKMT2ASMN1; SMN2MAP4K1 | |
| SCHEMBL5224173 | 0.83 | ALDH1A1 (0.52) | LMNAPOLBKMT2ASMN1; SMN2MAP4K1 | |
| SCHEMBL2761085 | 0.74 | DHODH (0.43) | LMNAMAP4K1DHODHMAPK14HTR6 | |
| SCHEMBL5224180 | 0.72 | SMN1; SMN2 (0.41) | LMNAPOLBKMT2ASMN1; SMN2MAP4K1 | |
| SCHEMBL5224673 | 0.71 | SMO (0.40) | LMNANR3C1DHODHMAPK14HTR6 | |
| SCHEMBL6313735 | 0.69 | HTR1A (0.59) | DHFRMAPK14HTR1AHTR1DHTR1B | |
| SCHEMBL14282302 | 0.68 | NPBWR1 (0.54) | LMNAPOLBKMT2ASMN1; SMN2HTR1A | |
| SCHEMBL14005327 | 0.68 | NPBWR1 (0.61) | LMNAPOLBKMT2ASMN1; SMN2 | |
| SCHEMBL30108226 | 0.67 | MELK (0.60) | KMT2ASMN1; SMN2MAP4K1ACVR1MELK | |
| SCHEMBL30108214 | 0.66 | HTR1A (0.64) | SMN1; SMN2DHFRHTR1AHTR2CHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611122-B1 | SUBSTITUTED PYRAZOLE COMPOUNDS | MERCK PATENT GMBH (DE) | 2007-06-13 | — | — | EP | disclosed |