Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 10/20 | 0.47 |
| ▸ | BCHE | P06276 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CTSD | P07339 | 7/20 | 0.44 |
| ▸ | BACE2 | Q9Y5Z0 | 7/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5224305 | 1.00 | BACE1 (0.47) | BACE1BCHEKDM4EMEN1KMT2A | |
| SCHEMBL3016198 | 0.90 | BACE1 (0.58) | BACE1BCHECTSDBACE2 | |
| SCHEMBL3016194 | 0.90 | BACE1 (0.58) | BACE1BCHECTSDBACE2 | |
| SCHEMBL5219646 | 0.88 | ADRB3 (0.43) | BACE1BCHEKDM4EMEN1KMT2A | |
| SCHEMBL5219638 | 0.88 | ADRB3 (0.43) | BACE1BCHEKDM4EMEN1KMT2A | |
| SCHEMBL5219515 | 0.86 | SLC2A1 (0.46) | MEN1KMT2AADRB1 | |
| SCHEMBL5219507 | 0.86 | SLC2A1 (0.46) | MEN1KMT2AADRB1 | |
| SCHEMBL5216394 | 0.84 | OPRM1 (0.47) | BACE1BCHEKDM4EMEN1KMT2A | |
| SCHEMBL5216401 | 0.84 | OPRM1 (0.47) | BACE1BCHEKDM4EMEN1KMT2A | |
| SCHEMBL5217761 | 0.83 | PLAAT3 (0.43) | MEN1KMT2AADRB1SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |