Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5232268 | 0.91 | BCL2L11 (0.39) | LMNAALDH1A1SMN1; SMN2TSHRHTT | |
| SCHEMBL2761238 | 0.89 | LMNA (0.51) | LMNAALDH1A1MAPTPOLBKMT2A | |
| SCHEMBL5230462 | 0.89 | HTR1A (0.47) | ALDH1A1SMN1; SMN2TSHRHTTHSD17B10 | |
| Hydrochloric Acid SCHEMBL1997591 | 0.88 | LMNA (0.50) | LMNAALDH1A1SMN1; SMN2HTTMAPT | |
| SCHEMBL5226495 | 0.86 | NPSR1 (0.44) | LMNAALDH1A1TSHRHTTMAPT | |
| SCHEMBL5228511 | 0.83 | MAPT (0.38) | ALDH1A1SMN1; SMN2TSHRHTTHSD17B10 | |
| SCHEMBL1999587 | 0.80 | LMNA (0.44) | LMNAALDH1A1HTTMAPTPOLB | |
| SCHEMBL2006339 | 0.79 | LMNA (0.44) | LMNAALDH1A1MAPTPOLBHRH3 | |
| SCHEMBL2761010 | 0.79 | MAPT (0.41) | LMNAHTTMAPTPOLBHTR1A | |
| SCHEMBL2761138 | 0.79 | LMNA (0.40) | LMNAHTTMAPTPOLBHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611122-B1 | SUBSTITUTED PYRAZOLE COMPOUNDS | MERCK PATENT GMBH (DE) | 2007-06-13 | — | — | EP | disclosed |