Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5224996 | 1.00 | OPRM1 (0.39) | OPRM1OPRD1OPRK1ALDH1A1NPSR1 | |
| SCHEMBL5223463 | 0.87 | OPRD1 (0.41) | OPRM1OPRD1OPRK1ABCB1BCHE | |
| SCHEMBL5223473 | 0.87 | OPRD1 (0.41) | OPRM1OPRD1OPRK1ABCB1BCHE | |
| SCHEMBL609658 | 0.84 | ANPEP (0.42) | OPRM1OPRD1OPRK1ALDH1A1ABCB1 | |
| SCHEMBL609656 | 0.84 | ANPEP (0.42) | OPRM1OPRD1OPRK1ALDH1A1ABCB1 | |
| SCHEMBL4869209 | 0.82 | ABCB1 (0.39) | OPRM1OPRD1OPRK1ABCB1BCHE | |
| SCHEMBL5219638 | 0.82 | ADRB3 (0.43) | OPRM1OPRD1OPRK1MAPTBCHE | |
| SCHEMBL5223492 | 0.82 | OPRM1 (0.40) | OPRM1OPRD1OPRK1ABCB1BCHE | |
| SCHEMBL5223500 | 0.82 | OPRM1 (0.40) | OPRM1OPRD1OPRK1ABCB1BCHE | |
| SCHEMBL4869199 | 0.82 | ABCB1 (0.39) | OPRM1OPRD1OPRK1ABCB1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |