Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 10/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | PHGDH | O43175 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6992479 | 0.87 | IRAK4 (0.42) | AAK1CYP3A4IRAK4TGFBR1PIK3C3 | |
| SCHEMBL5225197 | 0.86 | TGFBR1 (0.43) | AAK1CYP3A4IRAK4TGFBR1PIK3C3 | |
| SCHEMBL7026837 | 0.85 | IRAK4 (0.42) | AAK1IRAK4TGFBR1PIK3C3GSK3B | |
| SCHEMBL6990608 | 0.84 | AAK1 (0.41) | AAK1IRAK4TGFBR1PIK3C3NR3C2 | |
| SCHEMBL7020508 | 0.80 | TGFBR1 (0.40) | AAK1CYP3A4IRAK4TGFBR1PIK3C3 | |
| SCHEMBL5251219 | 0.75 | EGFR (0.57) | AAK1IRAK4TGFBR1PIK3C3GSK3B | |
| SCHEMBL5812808 | 0.75 | RIPK3 (0.41) | AAK1IRAK4TGFBR1PIK3C3GSK3B | |
| SCHEMBL29992322 | 0.72 | AAK1 (0.48) | AAK1CYP3A4IRAK4TGFBR1PIK3C3 | |
| SCHEMBL8670718 | 0.72 | FDPS (0.50) | AAK1CYP3A4IRAK4TGFBR1PIK3C3 | |
| SCHEMBL17643492 | 0.72 | AAK1 (0.48) | AAK1CYP3A4IRAK4TGFBR1PIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268474-A2 | SUBSTITUTED 1,3-THIAZOLE COMPOUNDS, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001074811-A2 | SUBSTITUTED 1,3-THIAZOLE COMPOUNDS, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-10-11 | — | — | WO | disclosed |