Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | COPS5 | Q92905 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | FBP1 | P09467 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1539908 | 0.80 | ALDH1A1 (0.45) | ALDH1A1HPGDCYP1A2COPS5MAPT | |
| SCHEMBL3098533 | 0.80 | ALDH1A1 (0.65) | ALDH1A1HPGDCYP1A2MAPTHSD17B10 | |
| SCHEMBL5221270 | 0.79 | ALDH1A1 (0.44) | ALDH1A1HPGDCYP1A2COPS5MAPT | |
| SCHEMBL3618179 | 0.78 | ALDH1A1 (0.42) | ALDH1A1HPGDCYP1A2COPS5MAPT | |
| SCHEMBL27821918 | 0.76 | GABRP (0.50) | ALDH1A1HPGDCYP1A2MAPTHSD17B10 | |
| SCHEMBL11338473 | 0.75 | GABRP (0.45) | ALDH1A1HPGDCYP1A2MAPTHSD17B10 | |
| SCHEMBL10585559 | 0.72 | ALDH1A1 (0.38) | ALDH1A1HPGDCYP1A2COPS5MAPT | |
| SCHEMBL25916483 | 0.72 | NOS1 (0.46) | ALDH1A1HPGDCYP1A2MAPTHSD17B10 | |
| SCHEMBL4998220 | 0.70 | GFER (0.43) | ALDH1A1HPGDCYP1A2COPS5MAPT | |
| SCHEMBL3585289 | 0.70 | SMN1; SMN2 (0.47) | ALDH1A1HPGDCYP1A2COPS5MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1525193-B1 | ACYLAMINOTHIAZOLE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2007-12-26 | — | — | EP | disclosed |
| EP-1525193-A2 | ACYLAMINOTHIAZOLE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2005-04-27 | — | — | EP | disclosed |
| WO-2004009565-A2 | ACYLAMINOTHIAZOLE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2004-01-29 | — | — | WO | disclosed |