Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRAP1 | Q12931 | 2/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11352069 | 1.00 | TRAP1 (0.47) | TRAP1CHRNA7ALDH1A1CYP1A2CYP2D6 | |
| Bromide SCHEMBL28914657 | 0.94 | ALDH1A1 (0.49) | TRAP1CHRNA7ALDH1A1CYP1A2CYP2D6 | |
| Bromide SCHEMBL15916470 | 0.84 | TRAP1 (0.44) | TRAP1CHRNA7ALDH1A1CYP1A2CYP2D6 | |
| Bromide SCHEMBL26905302 | 0.82 | ALDH1A1 (0.44) | TRAP1CHRNA7ALDH1A1CYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL4895935 | 0.82 | TDP1 (0.51) | TRAP1CHRNA7ALDH1A1CYP1A2CYP2D6 | |
| Bromide SCHEMBL20874269 | 0.82 | CHRNA7 (0.48) | TRAP1CHRNA7ALDH1A1CYP1A2CYP2D6 | |
| Bromide SCHEMBL20874314 | 0.82 | CHRNA7 (0.48) | TRAP1CHRNA7ALDH1A1CYP1A2CYP2D6 | |
| Bromide SCHEMBL29057269 | 0.81 | TSHR (0.54) | TRAP1CHRNA7ALDH1A1CYP1A2CYP2D6 | |
| Bromide SCHEMBL20874396 | 0.80 | CHRNA7 (0.47) | TRAP1CHRNA7ALDH1A1CYP1A2CYP2D6 | |
| Bromide SCHEMBL30082511 | 0.79 | TDP1 (0.48) | TRAP1CHRNA7ALDH1A1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129552-B2 | for transporting drugs or as gene transport vehicles, as solubilizers for drugs of low solubility in water, and themselves as active ingredients against diseases such as cancer or leishmaniosis; (Z)-6-octadecenyl-1-phospho-N,N,N-trimethylpropylammonium | MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V. (DE) | 2012-03-06 | — | — | US | disclosed |
| US-20080214849-A1 | PHOSPHOLIPIDS WITH UNSATURATED ALKYL AND ACYL CHAINS | MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSHAFTEN E.V. (DE) | 2008-09-04 | — | — | US | disclosed |
| EP-1102775-B1 | NOVEL PHOSPHOLIPIDS WITH UNSATURATED ALKYL AND ACYL CHAINS | MAX PLANCK GESELLSCHAFT (DE) | 2005-06-08 | — | — | EP | disclosed |
| EP-1102775-A1 | NOVEL PHOSPHOLIPIDS WITH UNSATURATED ALKYL AND ACYL CHAINS | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000008031-A1 | NOVEL PHOSPHOLIPIDS WITH UNSATURATED ALKYL AND ACYL CHAINS | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2000-02-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214849-A1 | PHOSPHOLIPIDS WITH UNSATURATED ALKYL AND ACYL CHAINS | PHOSPHO1, PLTP, SGMS1 | TRAP1 1259/4885CHRNA7 4429/4885ALDH1A1 4394/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.