Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | APEX1 | P27695 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 7/20 | 0.43 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL30082511 | 0.94 | TDP1 (0.48) | TDP1POLBAPEX1HTTTSHR | |
| Hydrochloric Acid SCHEMBL8151452 | 0.89 | TSHR (0.47) | TDP1POLBAPEX1HTTTSHR | |
| Bromide SCHEMBL31315837 | 0.88 | TSHR (0.46) | TDP1POLBAPEX1HTTTSHR | |
| Bromide SCHEMBL11352069 | 0.82 | TRAP1 (0.47) | TDP1TSHRALDH1A1CYP1A2CYP2D6 | |
| Bromide SCHEMBL52254 | 0.82 | TRAP1 (0.47) | TDP1TSHRALDH1A1CYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL26905339 | 0.79 | ALDH1A1 (0.44) | TDP1TSHRALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL15901492 | 0.79 | TDP1 (0.50) | TDP1POLBAPEX1HTTTSHR | |
| SCHEMBL4577427 | 0.78 | TDP1 (0.73) | TDP1POLBAPEX1HTTTSHR | |
| Bromide SCHEMBL28914657 | 0.78 | ALDH1A1 (0.49) | TDP1TSHRALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL13801022 | 0.78 | POLB (0.49) | TDP1POLBAPEX1HTTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1974914-B1 | Method of preparing lithographic printing plate | FUJIFILM CORP (JP) | 2014-02-26 | — | — | EP | disclosed |
| US-8361700-B2 | Lithographic printing plate precursor and method of preparing lithographic printing plate | FUJIFILM CORPORATION (JP) | 2013-01-29 | — | — | US | disclosed |
| US-20080241740-A1 | Support with photosensitive layer; reduce contact angle of water drops | FUJIFILM CORPORATION (JP) | 2008-10-02 | — | — | US | disclosed |
| EP-1974914-A2 | Lithographic printing plate precursor and method of preparing lithographic printing plate | FUJIFILM Corporation (JP) | 2008-10-01 | — | — | EP | disclosed |