Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5225103 | 0.81 | PTGS2 (0.48) | L3MBTL1SMN1; SMN2NPC1MITFMAPT | |
| SCHEMBL5226722 | 0.80 | KMT2A (0.43) | L3MBTL1SMN1; SMN2NPC1MITFMAPT | |
| SCHEMBL5223322 | 0.75 | BTK (0.50) | L3MBTL1SMN1; SMN2NPC1MITFMAPT | |
| SCHEMBL5226694 | 0.74 | KDM4E (0.43) | NPC1KDM4EKMT2A | |
| SCHEMBL5228063 | 0.73 | KMT2A (0.40) | L3MBTL1SMN1; SMN2NPC1MITFMAPT | |
| SCHEMBL5222128 | 0.73 | KMT2A (0.38) | L3MBTL1SMN1; SMN2NPC1MITFMAPT | |
| SCHEMBL5224031 | 0.72 | CNR1 (0.38) | L3MBTL1SMN1; SMN2NPC1MITFMAPT | |
| SCHEMBL5222119 | 0.72 | KMT2A (0.44) | L3MBTL1SMN1; SMN2NPC1MITFMAPT | |
| SCHEMBL5221905 | 0.72 | APP (0.49) | L3MBTL1SMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL5223497 | 0.72 | SMN1; SMN2 (0.54) | L3MBTL1SMN1; SMN2MAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1300399-B1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | KOWA CO (JP) | 2007-08-22 | — | — | EP | disclosed |
| US-6664256-B1 | Interleukin- 1 beta inhibitors | KOWA CO., LTD. (JP) | 2003-12-16 | — | — | US | disclosed |
| EP-1300399-A1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | Kowa Co., Ltd. (JP) | 2003-04-09 | — | — | EP | disclosed |