Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | CFTR | P13569 | 2/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALPL | P05186 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30712643 | 0.80 | ALDH1A1 (0.46) | SMN1; SMN2ALDH1A1HPGDKDM4EL3MBTL1 | |
| SCHEMBL26986682 | 0.80 | ALDH1A1 (0.46) | SMN1; SMN2ALDH1A1HPGDKDM4EL3MBTL1 | |
| SCHEMBL5224281 | 0.79 | PTGS2 (0.57) | SMN1; SMN2ALDH1A1MAPTHPGDKDM4E | |
| SCHEMBL5227063 | 0.78 | RAB9A (0.63) | SMN1; SMN2ALDH1A1MAPTHPGDKDM4E | |
| SCHEMBL5223978 | 0.77 | GAA (0.50) | SMN1; SMN2ALDH1A1MAPTHPGDKDM4E | |
| SCHEMBL5227004 | 0.76 | NPC1 (0.62) | SMN1; SMN2ALDH1A1MAPTBACE1KDM4E | |
| SCHEMBL4804463 | 0.76 | KDM1A (0.58) | SMN1; SMN2ALDH1A1MAPTHPGDKDM4E | |
| SCHEMBL5222119 | 0.76 | KMT2A (0.44) | SMN1; SMN2ALDH1A1MAPTKDM4EL3MBTL1 | |
| SCHEMBL5225103 | 0.75 | PTGS2 (0.48) | SMN1; SMN2ALDH1A1MAPTHPGDKDM4E | |
| SCHEMBL30712646 | 0.75 | ALDH1A1 (0.55) | SMN1; SMN2ALDH1A1MAPTHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1300399-B1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | KOWA CO (JP) | 2007-08-22 | — | — | EP | disclosed |
| US-6664256-B1 | Interleukin- 1 beta inhibitors | KOWA CO., LTD. (JP) | 2003-12-16 | — | — | US | disclosed |
| EP-1300399-A1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | Kowa Co., Ltd. (JP) | 2003-04-09 | — | — | EP | disclosed |