Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.37 |
| ▸ | TP53 | P04637 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | FABP1 | P07148 | 1/20 | 0.36 |
| ▸ | FABP6 | P51161 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5224994 | 0.96 | MAPT (0.35) | ALDH1A1TP53LMNAUSP2SMN1; SMN2 | |
| SCHEMBL5226151 | 0.88 | SMO (0.35) | ALDH1A1TP53LMNAUSP2KDM4E | |
| SCHEMBL5224989 | 0.86 | SCD5 (0.44) | TP53LMNASCD5THRBMAPT | |
| SCHEMBL5222920 | 0.83 | ALDH1A1 (0.41) | ALDH1A1TP53LMNAUSP2SMN1; SMN2 | |
| SCHEMBL5226166 | 0.83 | ALDH1A1 (0.41) | ALDH1A1TP53LMNAUSP2SMN1; SMN2 | |
| SCHEMBL5225926 | 0.81 | MCHR1 (0.41) | ALDH1A1TP53LMNAUSP2SMN1; SMN2 | |
| SCHEMBL5226838 | 0.80 | ALDH1A1 (0.41) | ALDH1A1TP53LMNAUSP2SMN1; SMN2 | |
| SCHEMBL5230509 | 0.79 | POLB (0.41) | ALDH1A1TP53SMN1; SMN2PKMPOLB | |
| SCHEMBL5229195 | 0.79 | POLB (0.40) | ALDH1A1TP53LMNAUSP2SMN1; SMN2 | |
| SCHEMBL5229335 | 0.78 | ALDH1A1 (0.42) | ALDH1A1TP53LMNAUSP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611122-B1 | SUBSTITUTED PYRAZOLE COMPOUNDS | MERCK PATENT GMBH (DE) | 2007-06-13 | — | — | EP | disclosed |