SCHEMBL5226488

SCHEMBL5226488

CCOC(=O)CN(Cc1ccc(OCCc2nc(-c3cccs3)oc2C)cc1)S(=O)(=O)N1CCc2ccccc21

nearest known ligand 0.51

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 16/20 0.51
PPARG P37231 16/20 0.51
PPARD Q03181 3/20 0.48
KDM4E B2RXH2 2/20 0.41
TP53 P04637 1/20 0.41
MAPT P10636 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5229603 0.94 PPARA (0.50) PPARAPPARGPPARDKDM4ETP53
SCHEMBL5227824 0.93 PPARA (0.45) PPARAPPARGPPARD
SCHEMBL5224845 0.93 PPARG (0.52) PPARAPPARGPPARD
SCHEMBL5230147 0.90 PPARA (0.49) PPARAPPARGPPARDKDM4ETP53
SCHEMBL5443596 0.90 PPARA (0.44) PPARAPPARGPPARD
SCHEMBL5428687 0.89 PPARA (0.42) PPARAPPARGPPARDKDM4ETP53
SCHEMBL14361086 0.89 PPARG (0.51) PPARAPPARGPPARD
SCHEMBL5227508 0.89 PPARA (0.49) PPARAPPARGTP53MAPT
SCHEMBL5226465 0.87 PPARA (0.44) PPARAPPARGKDM4E
SCHEMBL5434591 0.87 PPARG (0.48) PPARAPPARGTP53MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070254882-A1 Sulfamide Derivatives and Pharmaceutical Composition for Upregulation of Lipid Metabolism Comprising Same CRYSTAL GENOMICS, INC. (KR) 2007-11-01 US disclosed
EP-1778654-A1 SULFAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITION FOR UPREGULATION OF LIPID METABOLISM COMPRISING SAME Crystalgenomics, Inc. (KR) 2007-05-02 EP disclosed
WO-2006006832-A1 SULFAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITION FOR UPREGULATION OF LIPID METABOLISM COMPRISING SAME CRYSTALGENOMICS, INC. (KR) 2006-01-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070254882-A1 Sulfamide Derivatives and Pharmaceutical Composition for Upregulation of Lipid Metabolism Comprising Same SULT2A1, SPTLC2, SGMS2 PPARA 190/4885PPARG 399/4885PPARD 210/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.