SCHEMBL5434591

SCHEMBL5434591

CCOC(=O)CN(Cc1ccc(OCCc2nc(-c3ccc(C(F)(F)F)cc3)oc2C)cc1)S(=O)(=O)N1CCc2ccccc21

nearest known ligand 0.48

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PPARG P37231 17/20 0.48
PPARA Q07869 17/20 0.48
TP53 P04637 1/20 0.47
MAPT P10636 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5264766 0.96 PPARG (0.47) PPARGPPARATP53MAPT
SCHEMBL5227770 0.94 PPARG (0.45) PPARGPPARATP53MAPT
SCHEMBL5433687 0.93 PPARG (0.50) PPARGPPARA
SCHEMBL5225379 0.93 PPARG (0.54) PPARGPPARATP53MAPT
SCHEMBL5227508 0.93 PPARA (0.49) PPARGPPARATP53MAPT
SCHEMBL5429048 0.90 PPARG (0.44) PPARGPPARATP53MAPT
SCHEMBL5231626 0.89 PPARG (0.49) PPARGPPARA
SCHEMBL5225872 0.89 PPARG (0.52) PPARGPPARA
SCHEMBL5264954 0.89 PPARG (0.48) PPARGPPARATP53MAPT
SCHEMBL5224851 0.89 PPARG (0.53) PPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070254882-A1 Sulfamide Derivatives and Pharmaceutical Composition for Upregulation of Lipid Metabolism Comprising Same CRYSTAL GENOMICS, INC. (KR) 2007-11-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070254882-A1 Sulfamide Derivatives and Pharmaceutical Composition for Upregulation of Lipid Metabolism Comprising Same SULT2A1, SPTLC2, SGMS2 PPARG 399/4885PPARA 190/4885TP53 4759/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.