Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | LMNA | P02545 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.45 |
| ▸ | NPC1 | O15118 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | CTSV | O60911 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5229039 | 0.88 | KMT2A (0.44) | MAPTLMNASMN1; SMN2KMT2ANPC1 | |
| SCHEMBL5229049 | 0.88 | KMT2A (0.44) | MAPTLMNASMN1; SMN2KMT2ANPC1 | |
| SCHEMBL5225943 | 0.88 | ALDH1A1 (0.49) | MAPTLMNASMN1; SMN2KMT2ANPC1 | |
| SCHEMBL5225949 | 0.88 | ALDH1A1 (0.49) | MAPTLMNASMN1; SMN2KMT2ANPC1 | |
| SCHEMBL4978620 | 0.87 | MAPT (0.50) | MAPTLMNASMN1; SMN2KMT2ANPC1 | |
| SCHEMBL5222469 | 0.83 | ALDH1A1 (0.44) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL4976760 | 0.78 | ALDH1A1 (0.44) | MAPTLMNASMN1; SMN2KMT2ANPC1 | |
| SCHEMBL4978503 | 0.77 | KMT2A (0.42) | MAPTLMNASMN1; SMN2KMT2ANPC1 | |
| SCHEMBL4978681 | 0.76 | MAPT (0.41) | MAPTLMNASMN1; SMN2KMT2ANPC1 | |
| SCHEMBL5223908 | 0.76 | ALDH1A1 (0.44) | MAPTLMNASMN1; SMN2KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487824-B1 | DIAMINO-PYRIMIDINES AND THEIR USE AS ANGIOGENESIS INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2007-06-20 | — | — | EP | disclosed |