Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 2/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 11/20 | 0.44 |
| ▸ | F2 | P00734 | 8/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5228024 | 0.86 | HTR2C (0.42) | SMOROCK2LMNANR3C1 | |
| SCHEMBL5225751 | 0.85 | SMO (0.54) | SMOALDH1A1KDM4EHTTGAA | |
| SCHEMBL5226797 | 0.84 | SMO (0.61) | SMOALDH1A1KDM4EGAALMNA | |
| SCHEMBL5225265 | 0.83 | SMO (0.59) | SMOALDH1A1KDM4EHTTGAA | |
| SCHEMBL5229662 | 0.82 | SMO (0.58) | SMOROCK2ALDH1A1KDM4EHTT | |
| SCHEMBL5228505 | 0.80 | F10 (0.48) | F10F2 | |
| SCHEMBL5224144 | 0.79 | HTR2C (0.38) | SMOROCK2F10F2NR3C1 | |
| SCHEMBL2001554 | 0.79 | SMO (0.50) | SMOROCK2F10F2NR3C1 | |
| SCHEMBL5228047 | 0.78 | HTR2C (0.37) | ROCK2ALDH1A1KDM4EHTTF10 | |
| SCHEMBL5227619 | 0.78 | F10 (0.42) | F10F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611122-B1 | SUBSTITUTED PYRAZOLE COMPOUNDS | MERCK PATENT GMBH (DE) | 2007-06-13 | — | — | EP | disclosed |