Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 4/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5226797 | 0.86 | SMO (0.61) | SMOALDH1A1KDM4ELMNAGAA | |
| SCHEMBL5227214 | 0.85 | SMO (0.52) | SMOALDH1A1KDM4ELMNAGAA | |
| SCHEMBL5225265 | 0.84 | SMO (0.59) | SMOALDH1A1KDM4ELMNAGAA | |
| SCHEMBL5229662 | 0.83 | SMO (0.58) | SMOALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL5226907 | 0.80 | DRD4 (0.43) | SMOALDH1A1MAPTL3MBTL1 | |
| SCHEMBL5224226 | 0.79 | L3MBTL1 (0.36) | SMOHRH3ALDH1A1KDM4ENR3C1 | |
| SCHEMBL5228140 | 0.75 | NR3C1 (0.48) | SMOLMNANR3C1MAPT | |
| SCHEMBL5225922 | 0.75 | L3MBTL1 (0.53) | SMOALDH1A1KDM4ELMNANR3C1 | |
| SCHEMBL5230607 | 0.73 | DRD4 (0.46) | SMOALDH1A1NR3C1MAPTL3MBTL1 | |
| SCHEMBL2761177 | 0.73 | DRD4 (0.42) | SMOALDH1A1KDM4EHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611122-B1 | SUBSTITUTED PYRAZOLE COMPOUNDS | MERCK PATENT GMBH (DE) | 2007-06-13 | — | — | EP | disclosed |