Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | ALPI | P09923 | 1/20 | 0.39 |
| ▸ | ALPG | P10696 | 1/20 | 0.39 |
| ▸ | SMO | Q99835 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | PDE2A | O00408 | 2/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | USP7 | Q93009 | 1/20 | 0.37 |
| ▸ | PDCD1LG2 | Q9BQ51 | 2/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5227214 | 0.86 | SMO (0.52) | LMNASMONR3C1ROCK2 | |
| SCHEMBL5227619 | 0.84 | F10 (0.42) | HTR2CMCHR1USP7 | |
| SCHEMBL5230174 | 0.83 | DRD4 (0.46) | DRD2DRD4DRD3TP53ALPI | |
| SCHEMBL5227445 | 0.83 | DRD4 (0.46) | DRD2DRD4DRD3SMONR3C1 | |
| SCHEMBL5226907 | 0.83 | DRD4 (0.43) | MCHR1DRD2DRD4DRD3TP53 | |
| SCHEMBL5230607 | 0.82 | DRD4 (0.46) | MCHR1DRD2DRD4DRD3TP53 | |
| SCHEMBL5224144 | 0.81 | HTR2C (0.38) | HTR2CMCHR1SMONR3C1ROCK2 | |
| SCHEMBL5227774 | 0.81 | DRD3 (0.45) | MCHR1DRD2DRD4DRD3TP53 | |
| SCHEMBL2001554 | 0.79 | SMO (0.50) | HTR2CMCHR1DRD2DRD4DRD3 | |
| SCHEMBL5907351 | 0.79 | F10 (0.44) | CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611122-B1 | SUBSTITUTED PYRAZOLE COMPOUNDS | MERCK PATENT GMBH (DE) | 2007-06-13 | — | — | EP | disclosed |