Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 3/20 | 0.43 |
| ▸ | CTSS | P25774 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5227254 | 1.00 | ATM (0.44) | ATMCTSLCTSSALDH1A1CYP1A2 | |
| SCHEMBL4657463 | 0.93 | OPRK1 (0.42) | ATMCTSLCTSSALDH1A1CYP1A2 | |
| SCHEMBL4657462 | 0.93 | OPRK1 (0.42) | ATMCTSLCTSSALDH1A1CYP1A2 | |
| SCHEMBL3343179 | 0.91 | TRPM8 (0.48) | ATMCTSLCTSSALDH1A1CYP1A2 | |
| SCHEMBL3343181 | 0.91 | TRPM8 (0.48) | ATMCTSLCTSSALDH1A1CYP1A2 | |
| SCHEMBL5225794 | 0.90 | CTSL (0.39) | ATMCTSLCTSSALDH1A1CYP1A2 | |
| SCHEMBL3343158 | 0.85 | TRPM8 (0.45) | ATMCTSLCTSSALDH1A1CYP1A2 | |
| SCHEMBL3343159 | 0.85 | TRPM8 (0.45) | ATMCTSLCTSSALDH1A1CYP1A2 | |
| SCHEMBL3343122 | 0.84 | TRPM8 (0.44) | ATMCTSLCTSSALDH1A1CYP1A2 | |
| SCHEMBL3345241 | 0.84 | TP53 (0.47) | CTSLCTSSALDH1A1CYP1A2CTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1845089-A1 | Novel lactams and uses thereof | AstraZeneca AB (SE) | 2007-10-17 | — | — | EP | disclosed |
| US-5055464-A | Cognition activators, diuretics, antiulcer agents | YOSHITOMI PHARMACEUTICAL INDUSTRIES LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0322779-A2 | Benzolactam compounds and pharmaceutical uses thereof | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1989-07-05 | — | — | EP | disclosed |
| US-4539150-A | HYPOTENSIVE AGENTS, SULFIDING, CYCLIZATION | MITSUI TOATSU CHEMICALS, INC. (JP) | 1985-09-03 | — | — | US | disclosed |