Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | LTA4H | P09960 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.53 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | THRB | P10828 | 3/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.53 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5084989 | 0.92 | ITGB3 (0.52) | KDM4ELTA4HMEN1KMT2AALDH1A1 | |
| SCHEMBL4687657 | 0.90 | ALDH1A1 (0.55) | KDM4EMEN1KMT2AALDH1A1THRB | |
| SCHEMBL4684740 | 0.85 | PSMB1 (0.53) | KDM4ELTA4HMEN1KMT2APSMB1 | |
| SCHEMBL4684742 | 0.85 | PSMB1 (0.53) | KDM4ELTA4HMEN1KMT2APSMB1 | |
| SCHEMBL4685989 | 0.84 | ALDH1A1 (0.48) | MEN1KMT2AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL3815002 | 0.84 | PSMB1 (0.51) | KDM4ELTA4HMEN1KMT2APSMB1 | |
| SCHEMBL4686341 | 0.83 | SMN1; SMN2 (0.60) | LMNASMN1; SMN2MAPK1POLB | |
| SCHEMBL5505866 | 0.82 | SMN1; SMN2 (0.56) | LMNASMN1; SMN2MAPK1POLB | |
| SCHEMBL3645386 | 0.82 | SMN1; SMN2 (0.56) | LMNASMN1; SMN2MAPK1POLB | |
| SCHEMBL4683920 | 0.81 | SMN1; SMN2 (0.58) | MEN1KMT2ALMNASMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781649-A2 | SUBSTITUTED HYDANTOINS | F. Hoffmann-Roche AG (CH) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006018188-A2 | SUBSTITUTED HYDANTOINS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-02-23 | — | — | WO | disclosed |