Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 10/20 | 0.72 |
| ▸ | ADORA2A | P29274 | 9/20 | 0.72 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.72 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GMNN | O75496 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4623457 | 0.81 | ADORA2A (0.59) | ADORA2BADORA2AADORA1ADORA3HPGD | |
| SCHEMBL2958488 | 0.80 | ADORA2A (0.58) | ADORA2BADORA2AADORA1ADORA3HPGD | |
| SCHEMBL8118476 | 0.80 | ADORA1 (1.00) | ADORA2BADORA2AADORA1ADORA3MEN1 | |
| SCHEMBL5229734 | 0.79 | ADORA2B (1.00) | ADORA2BADORA2AADORA1ADORA3MEN1 | |
| SCHEMBL11021594 | 0.79 | ADORA2A (0.53) | ADORA2BADORA2AADORA1 | |
| SCHEMBL9645577 | 0.78 | ADORA2A (0.55) | ADORA2BADORA2AADORA1ADORA3HPGD | |
| SCHEMBL9645551 | 0.77 | ADORA1 (0.95) | ADORA2BADORA2AADORA1ADORA3MEN1 | |
| SCHEMBL5227560 | 0.76 | ADORA1 (0.90) | ADORA2BADORA2AADORA1ADORA3MEN1 | |
| SCHEMBL9645161 | 0.76 | ADORA2A (0.54) | ADORA2BADORA2AADORA1ADORA3HPGD | |
| SCHEMBL11015546 | 0.76 | ADORA2A (0.54) | ADORA2BADORA2AADORA1ADORA3HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1092435-B1 | REMEDIES FOR DIABETES | KYOWA HAKKO KOGYO KK (JP) | 2007-04-04 | — | — | EP | disclosed |
| US-6489331-B1 | A CONDENSED PURINE DERIVATIVE AS AN ACTIVE INGREDIENT AS AN ENHANCER OF INSULIN SECRETION AND A MEDICAMENT FOR THE TREATMENT OF DIABETES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2002-12-03 | — | — | US | disclosed |
| EP-1092435-A1 | REMEDIES FOR DIABETES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-04-18 | — | — | EP | disclosed |