Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 8/20 | 0.51 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5237280 | 0.86 | CES1 (0.49) | IDH1CES1ALDH1A1KMT2AMAPT | |
| SCHEMBL5230286 | 0.85 | IDH1 (0.48) | IDH1CES1ALDH1A1KMT2AMAPT | |
| SCHEMBL5227591 | 0.82 | CDK1 (0.52) | IDH1ALDH1A1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL5231329 | 0.81 | IDH1 (0.48) | IDH1CES1ALDH1A1KMT2AMAPT | |
| SCHEMBL5231820 | 0.79 | HTT (0.55) | IDH1CES1ALDH1A1KMT2AMAPT | |
| SCHEMBL5227161 | 0.79 | MEN1 (0.48) | ALDH1A1KMT2AMAPTSMN1; SMN2GAA | |
| SCHEMBL5228023 | 0.77 | CA2 (0.49) | ALDH1A1KMT2AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL5228010 | 0.77 | ALDH1A1 (0.43) | IDH1CES1ALDH1A1KMT2AMAPT | |
| SCHEMBL5231082 | 0.76 | ALDH1A1 (0.43) | IDH1ALDH1A1KMT2AMAPTGAA | |
| SCHEMBL5234203 | 0.76 | ALDH1A1 (0.42) | IDH1ALDH1A1KMT2AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1519932-B1 | BISARYLSULFONAMIDE COMPOUNDS AND THEIR USE IN CANCER THERAPY | CYCLACEL LTD (GB) | 2007-10-03 | — | — | EP | claimed |